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AZT

Some harmful effects of AZT disappear after it is discontinued

After eleven patients on AZT were taken off AZT in favor of an experimental vaccine, ten of the eleven recovered cellular immune functions within a week or two (Scolaro, et al., 1991).  The vaccine consisted of an HIV strain that was presumed to be harmless because it had been isolated from a healthy carrier who had been infected by the virus for at least 10 years.  Since there was no evidence that the hypothetical vaccine strain differed from that by which the patients were already naturally vaccinated, the only relevant difference between the patients before and during the vaccine trial was the termination of their AZT treatment.

    Four patients with pneumonia developed a severe depression in blood cell counts due to an inhibition of blood-cell making organs (such as bone marrow) after the initiation of AZT therapy.  Three out of four recovered within 4 to 5 weeks after AZT was discontinued (Gill, et al., 1987).

      1The United States Bureau of Justice doesn't keep any records for poppers, because they consider poppers (nitrite inhalants) harmless, 'soft drugs', but there some numbers available indicating that in 1980, 250 million doses of poppers were consumed in the United States.  At that time, Burroughs-Wellcome was still producing poppers.

      2the other three are deoxyadenosine, deoxycytosine, and deoxyguanosine

      3micromolar amounts are only 1/1000th the amounts of AZT found in the millimolar range

Horwitz, J.P., Chua, J., and Noel, M. (1964) J. Org. Chem. 29: 2076.
Cohen, S.S. (1987) Antiretroviral Therapy for AIDS.  New Engl J. Med 317: 629.
Yarchoan, R. and Broder, S. (1987a) Antiretroviral therapy for AIDS.  New Engl. J. Med. 317: 630.
Yarchoan, R., Pluda, J.M., Perno, C.F., Mitsuya, H. and Broder, S. (1991) Antiretroviral therapy of
    Human Immunodeficiency Virus Infection: Current Strategies and Challenges for the Future.
    Blood 78: 859-884.
Cretton, E.M., Xie, M.Y., Bevan, R.J., Goudgaon, N.M., Schinzai, R.F. and Sommadossi, J.P. (1991)
    Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of
    formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
    Molec. Pharmac., 39:  258-266.
Chernov, H.I., (1986) Document on New Drug Application 19-655.  Food and Drug Administration,

    Washington, D.C.
Elwell, L.P., Ferone, R., Freeman, G.A., Fyfe, J.A., Hill, J.A., Ray, P.H., Richards, C.A., Singer, S.C.,
    Knick, C.B., Rideout, J.L. and Zimmerman, T.P. (1987) Antibacterial Activity and mechanism of Action
    3'-azido-3'-deoxythymidine (BW A509U). Antimicrob. Agents Chemotherapy, 31: 274-280.

Yarchoan, R. and Broder, S. (1987b) Development of Antiretroviral Therapy for the Acquired
    Immunodeficiency Syndrome and Related Disorders.  New England Journal of Medicine, 316: 557-564.
Smothers, K. (1991) Pharmacology and Toxicology of AIDS Therapies.  The AIDS Reader 1: 29-35.

If you believe that you have a case against the makers of AZT and the doctor who prescribed it, then visit Medifocus.com,Inc.
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